Purine anti-metabolite attenuates nuclear factor κB and related pro-inflammatory cytokines in experimental vasospasm

Abstract

Increased nuclear factor κB (NF-κB) bioexpression, as well as TNF-α, IL-1β and IL-6 levels, were observed after aneurysmal subarachnoid hemorrhage (SAH). It is of interest to investigate the effect of 6-mercaptopurine (6-mp) on cytokines/NF-κB in this SAH model. A rodent double-hemorrhage SAH model was employed. Serum and cerebrospinal fluid (CSF) samples… (More)
DOI: 10.1007/s00701-012-1452-8

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@article{Chang2012PurineAA, title={Purine anti-metabolite attenuates nuclear factor κB and related pro-inflammatory cytokines in experimental vasospasm}, author={Chih-Zen Chang and S Wu and Chih-Long Lin and Shiuh-Lin Hwang and Aij-lie Kwan}, journal={Acta Neurochirurgica}, year={2012}, volume={154}, pages={1877-1885} }