Purine and pyrimidine base and nucleoside concentrations in human cerebrospinal fluid and plasma

@article{Eells1983PurineAP,
  title={Purine and pyrimidine base and nucleoside concentrations in human cerebrospinal fluid and plasma},
  author={Janis Thane Eells and Reynold Spector},
  journal={Neurochemical Research},
  year={1983},
  volume={8},
  pages={1451-1457}
}
Purine and pyrimidine base and nucleoside levels were determined in adult human lumbar (CSF) and plasma by reversed-phase high performance liquid chromatography (HPLC). Guanine, thymine, cytosine and uracil were not detectable (<0.1 μM) in human CSF or plasma. Adenine was detectable in plasma (0.3 μM) but was not found in CSF (<0.2 μM). Hypoxanthine and xanthine levels in CSF were each approximately 2.5 μM. Plasma levels of hypoxanthine and xanthine were considerably lower (0.4–0.6 μM). Purine… CONTINUE READING