Purine Nucleosides and Nucleotides Unequivocally in the Syn Conformation ‘ . Guanosine and 5-GMP with 8-ter /-Butyl and 8-( ß-Hydroxyisopropyl ) Substituents

@inproceedings{Pless2013PurineNA,
  title={Purine Nucleosides and Nucleotides Unequivocally in the Syn Conformation ‘ . Guanosine and 5-GMP with 8-ter /-Butyl and 8-( \ss-Hydroxyisopropyl ) Substituents},
  author={Reynaldo C. Pless and Lech W. Dudycz and Ryszard Stolarski and David Shugar},
  year={2013}
}
Direct alkylation via a free radical reaction was utilized to prepare 8-fer£-butylguanosine-5'phosphate; this was dephosphorylated with alkaline phosphatase to give the parent nucleoside. The 8 (a-hydroxyisopropyl) derivatives of 5'-GMP and guanosine were prepared in an analogous manner. The foregoing products, which are necessarily in the syn conformation… CONTINUE READING