Purine Nucleoside Phosphorylase

@inproceedings{Stoeckler1985PurineNP,
  title={Purine Nucleoside Phosphorylase},
  author={J. Stoeckler and R. Parks},
  year={1985}
}
It has long been appreciated that purine nucleoside phosphorylase (PNP; purine nucleoside: orthophosphate ribosyltransferase, EC 2.4.2.1) may play a role in cancer chemotherapy by catalyzing the degradation of potentially cytotoxic purine deoxynucleoside analogs, e.g., 2′-deoxy-6-thioguanosine. More recently, the identification of an immunodeficiency disorder associated with a deficiency in PNP (Giblett et al., 1975) has drawn attention to this enzyme as a possible target for the design of… Expand
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