Purified poloxamer 188 for treatment of acute vaso-occlusive crisis of sickle cell disease: A randomized controlled trial.

@article{Orringer2001PurifiedP1,
  title={Purified poloxamer 188 for treatment of acute vaso-occlusive crisis of sickle cell disease: A randomized controlled trial.},
  author={Eugene P. Orringer and James F. Casella and Kenneth I Ataga and Mabel Koshy and Patricia E Adams-Graves and Lori Luchtman-Jones and Theodore Wun and Masayo Watanabe and F. James Shafer and Abdullah Kutlar and Miguel Abboud and Marilyn Steinberg and Brian K. Adler and Paul Swerdlow and Calogero Terregino and Suzanne L. Saccente and Beatrice A Files and Samir Ballas and Robyn M Brown and Slawomir Wojtowicz-Praga and J Michael Grindel},
  journal={JAMA},
  year={2001},
  volume={286 17},
  pages={2099-106}
}
CONTEXT Sickle cell disease (SCD) can cause severe painful episodes that are often thought to be caused by vaso-occlusion. The current therapy for these uncomplicated painful episodes includes hydration, oxygen, and analgesics. Purified poloxamer 188 may increase tissue oxygenation and thereby reduce inflammation, pain, and the overall duration of such painful episodes in patients with SCD. OBJECTIVE To compare the duration of painful episodes in patients with SCD treated with purified… CONTINUE READING
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