Purified human serum PON1 does not protect LDL against oxidation in the in vitro assays initiated with copper or AAPH.

@article{Teiber2004PurifiedHS,
  title={Purified human serum PON1 does not protect LDL against oxidation in the in vitro assays initiated with copper or AAPH.},
  author={John F. Teiber and Dragomir I Draganov and Bert N La Du},
  journal={Journal of lipid research},
  year={2004},
  volume={45 12},
  pages={2260-8}
}
Purified serum paraoxonase (PON1) had been shown to attenuate the oxidation of LDL in vitro. We critically reevaluated the antioxidant properties of serum PON1 in the in vitro assays initiated with copper or the free radical generator 2,2'-azobis-2-amidinopropane hydrochloride (AAPH). The antioxidant activity of different purified PON1 preparations did not correlate with their arylesterase (AE), lactonase, or phospholipase A2 activities or with the amounts of detergent or protein. Dialysis of… CONTINUE READING

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