Purified hematopoietic stem cells can differentiate into hepatocytes in vivo

@article{Lagasse2000PurifiedHS,
  title={Purified hematopoietic stem cells can differentiate into hepatocytes in vivo},
  author={Eric Lagasse and Heather Connors and Muhsen J Al-Dhalimy and Michael Reitsma and Monika Dohse and Linda Osborne and Xin Wang and Milton L Finegold and Irving L Weissman and Markus Grompe},
  journal={Nature Medicine},
  year={2000},
  volume={6},
  pages={1229-1234}
}
The characterization of hepatic progenitor cells is of great scientific and clinical interest. Here we report that intravenous injection of adult bone marrow cells in the FAH−/− mouse, an animal model of tyrosinemia type I, rescued the mouse and restored the biochemical function of its liver. Moreover, within bone marrow, only rigorously purified hematopoietic stem cells gave rise to donor-derived hematopoietic and hepatic regeneration. This result seems to contradict the conventional… CONTINUE READING
Highly Influential
This paper has highly influenced 18 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS