Purified Canola Lutein Selectively Inhibits Specific Isoforms of Mammalian DNA Polymerases and Reduces Inflammatory Response

@article{Horie2010PurifiedCL,
  title={Purified Canola Lutein Selectively Inhibits Specific Isoforms of Mammalian DNA Polymerases and Reduces Inflammatory Response},
  author={Shohei Horie and Chiaki Okuda and Takatoshi Yamashita and Kenichi Watanabe and Kouji Kuramochi and Masashi Hosokawa and Toshifumi Takeuchi and Makiko Kakuda and Kazuo Miyashita and Fumio Sugawara and Hiromi Yoshida and Yoshiyuki Mizushina},
  journal={Lipids},
  year={2010},
  volume={45},
  pages={713-721}
}
In the screening of DNA polymerase (pol) inhibitor, we isolated lutein, a carotenoid, from the crude (unrefined) pressed oil of canola (low erucic acid rapeseed, Brassica napus L.). Commercially prepared carotenoids such as lutein (1), zeaxanthin (2), β-cryptoxanthin (3), astaxanthin (4), canthaxanthin (5), β-carotene (6), lycopene (7), capsanthin (8), fucoxanthin (9) and fucoxanthinol (10), were investigated for the inhibitory activities of pols. Compounds 1, 2 and 8 exhibited strong… 

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