Purification of plant calmodulin by fluphenazine-Sepharose affinity chromatography.

@article{Charbonneau1979PurificationOP,
  title={Purification of plant calmodulin by fluphenazine-Sepharose affinity chromatography.},
  author={Hubert Charbonneau and Milton J. Cormier},
  journal={Biochemical and biophysical research communications},
  year={1979},
  volume={90 3},
  pages={
          1039-47
        }
}
The calcium-dependent binding of phenothiazine drugs to calmodulin (Levin, R. M. and Weiss, B. (1977) Mol. Pharmacol. 13, 690–697) has been utilized to develop a rapid purification procedure for calmodulin based on fluphenazine-Sepharose affinity chromatography. Calmodulin from plant, a fungus, porcine brain and the coelenterate, Renillareniformis, were easily purified by the calcium-dependent binding of calmodulin to fluphenazine-Sepharose. 
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