Purification of neurocatin, a neuroregulatory factor from brain.

@article{Yee1990PurificationON,
  title={Purification of neurocatin, a neuroregulatory factor from brain.},
  author={Daniel K. Yee and Peter Pastuszko and Anna Pastuszko and David F Wilson},
  journal={Neuroscience letters},
  year={1990},
  volume={114 2},
  pages={213-9}
}
A neuroregulatory factor (neurocatin) has been isolated from bovine brain. Neurocatin is a powerful affector of catecholamine metabolism in synaptosomes isolated from rat brain, causing increased formation of norepinephrine (NE) and decreased formation of 3,4-dihydroxyphenylacetic acid (DOPAC). The ratio NE/DOPAC in synaptosomes has been used to measure the neurocatin content of samples during isolation. Neurocatin has now been purified to a single chromatographic peak by high-resolution HPLC… CONTINUE READING