Purification of large neuromedin N (NMN) from canine intestine and its identification as NMN-125.

  title={Purification of large neuromedin N (NMN) from canine intestine and its identification as NMN-125.},
  author={R. Carraway and S. P. Mitra},
  journal={Biochemical and biophysical research communications},
  volume={179 1},
  • R. Carraway, S. P. Mitra
  • Published 1991
  • Biology, Medicine
  • Biochemical and biophysical research communications
  • A large molecular form of neuromedin N (NMN), a neurotensin (NT)-related peptide, was purified to homogeneity from canine ileal mucosa. The amino acid sequence of its N-terminal 20 residues was found to be SDSEEEMKALEADLLTNMHT, which is identical to residues 24-43 of the cDNA-predicted NT/NMN precursor. Prior work had indicated that the NMN moiety was located at the C-terminus of large NMN. Having now defined both the N-terminus and C-terminus of large NMN, we note that this molecule must be… CONTINUE READING
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