Purification of erythroid progenitor cells and characterization of erythropoietin receptors.

Abstract

Highly purified murine and human erythroid progenitor cells at the colony-forming unit-erythroid (CFU-E) stage of development were prepared and recombinant human erythropoietin (rEp) was radioiodinated with retention of full biological activity. Specific binding of 125I-rEp to the murine cells revealed 950 receptors on the cell surface. Three hundred had a… (More)

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