Purification of a 17beta-hydroxysteroid dehydrogenase of human placenta and studies on its transhydrogenase function.

@article{Jarabak1962PurificationOA,
  title={Purification of a 17beta-hydroxysteroid dehydrogenase of human placenta and studies on its transhydrogenase function.},
  author={J W Jarabak and J. Alan Adams and H. Guy Williams-Ashman and Paul Talalay},
  journal={The Journal of biological chemistry},
  year={1962},
  volume={237},
  pages={345-57}
}
This paper describes methods for the extensive purification of a soluble 17@-hydroxysteroid dehydrogenasel of human placenta. This single enzyme appears to be responsible for the entire 17/3estradiol-mediated transfer of hydrogen between pyridine nucleotides in soluble extracts of this tissue. Experiments which were reported in 1958 (2, 3) showed that soluble enzyme preparations derived from human placenta promoted a reversible transhydrogenation between pyridine nucleotides in the presence of… CONTINUE READING

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