Purification and unique properties of mammary epithelial stem cells

@article{Stingl2006PurificationAU,
  title={Purification and unique properties of mammary epithelial stem cells},
  author={John Stingl and Peter D. Eirew and Ian Ricketson and Mark Shackleton and François Vaillant and David Choi and H. Irene Li and Connie J. Eaves},
  journal={Nature},
  year={2006},
  volume={439},
  pages={993-997}
}
Elucidation of the cellular and molecular mechanisms that maintain mammary epithelial tissue integrity is of broad interest and paramount to the design of more effective treatments for breast cancer. Evidence from both in vitro and in vivo experiments suggests that mammary cell differentiation is a hierarchical process originating in an uncommitted stem cell with self-renewal potential. However, analysis of the properties and regulation of mammary stem cells has been limited by a lack of… CONTINUE READING
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