Purification and properties of heparin-releasable lipoprotein-associated coagulation inhibitor.

@article{Novotny1991PurificationAP,
  title={Purification and properties of heparin-releasable lipoprotein-associated coagulation inhibitor.},
  author={William F. Novotny and Mark O. Palmier and T C Wun and George J. Broze and Joseph P. Miletich},
  journal={Blood},
  year={1991},
  volume={78 2},
  pages={394-400}
}
The lipoprotein-associated coagulation inhibitor (LACI) is present in vivo in at least three different pools: sequestered in platelets, associated with plasma lipoproteins, and released into plasma by intravenous heparin, possibly from vascular endothelium. In this study we have purified the heparin-relesable form of LACI from post-heparin plasma and show that it is structurally different from lipoprotein LACI. The purification scheme uses heparin-agarose chromatography, immunoaffinity… CONTINUE READING
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