Purification and preliminary sequencing of Tc-45, an immunodominant Trypanosoma cruzi antigen: absence of homology with cruzipain, cruzain, and a 46-kilodalton protein.

@article{Aguilln1995PurificationAP,
  title={Purification and preliminary sequencing of Tc-45, an immunodominant Trypanosoma cruzi antigen: absence of homology with cruzipain, cruzain, and a 46-kilodalton protein.},
  author={Juan Carlos Aguill{\'o}n and Carlos J Bustos and P. Vallejos and Tamara Hermosilla and Antonio Morell{\'o} and Yolanda Repetto and Ulf Hellman and Anders Orn and A dos S Ferreira},
  journal={The American journal of tropical medicine and hygiene},
  year={1995},
  volume={53 2},
  pages={211-5}
}
In spite of being separated by more than 20 million years of evolution, the murine and human immune systems share extensive similarities. Thus, experimental results obtained with the murine model may have predictive value for human Chagas' disease. Challenge of the H-2 congenic mouse stains A.SW (H-2s) and A.CA (H-2f) with Trypanosoma cruzi yields different results. The A.CA animals die approximately 12 days postinfection, while A.SW mice survive indefinitely. A 45-kD protein (Tc45), an antigen… CONTINUE READING