Purification and preliminary characterization of brain aspartoacylase.

@article{Moore2003PurificationAP,
  title={Purification and preliminary characterization of brain aspartoacylase.},
  author={Roger A. Moore and Johanne Le Coq and Christopher R Faehnle and Ronald E. Viola},
  journal={Archives of biochemistry and biophysics},
  year={2003},
  volume={413 1},
  pages={1-8}
}
Aspartoacylase catalyzes the deacetylation of N-acetylaspartic acid (NAA) in the brain to produce acetate and L-aspartate. An aspartoacylase deficiency, with concomitant accumulation of NAA, is responsible for Canavan disease, a lethal autosomal recessive disorder. To examine the mechanism of this enzyme the genes encoding murine and human aspartoacylase were cloned and expressed in Escherichia coli. A significant portion of the enzyme is expressed as soluble protein, with the remainder found… CONTINUE READING

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