Purification and molecular cloning of an inducible gram-negative bacteria-binding protein from the silkworm, Bombyx mori.

@article{Lee1996PurificationAM,
  title={Purification and molecular cloning of an inducible gram-negative bacteria-binding protein from the silkworm, Bombyx mori.},
  author={Won Jae Lee and Jeffrey D. Lee and Vladimir V. Kravchenko and Richard J Ulevitch and Paul T. Brey},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 15},
  pages={7888-93}
}
A 50-kDa hemolymph protein, having strong affinity to the cell wall of Gram(-) bacteria, was purified from the hemolymph of the silkworm, Bombyx mori. The cDNA encoding this Gram(-) bacteria-binding protein (GNBP) was isolated from an immunized silkworm fat body cDNA library and sequenced. Comparison of the deduced amino acid sequence with known sequences revealed that GNBP contained a region displaying significant homology to the putative catalytic region of a group of bacterial beta-1,3… CONTINUE READING
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