Purification and crystallization of the cystic fibrosis transmembrane conductance regulator (CFTR).

@article{Rosenberg2004PurificationAC,
  title={Purification and crystallization of the cystic fibrosis transmembrane conductance regulator (CFTR).},
  author={Mark F. Rosenberg and Alhaji Bukar Kamis and Luba A. Aleksandrov and Robert Curtis Ford and John R. Riordan},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 37},
  pages={39051-7}
}
The cystic fibrosis transmembrane conductance regulator (CFTR) is a membrane protein that is mutated in patients suffering from cystic fibrosis. Here we report the purification and first crystallization of wild-type human CFTR. Functional characterization of the material showed it to be highly active. Electron crystallography of negatively stained two-dimensional crystals of CFTR has revealed the overall architecture of this channel for two different conformational states. These show a strong… CONTINUE READING

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