Purification and comparative neurotoxicity of the trichothecenes satratoxin G and roridin L2 from Stachybotrys chartarum.

@article{Islam2009PurificationAC,
  title={Purification and comparative neurotoxicity of the trichothecenes satratoxin G and roridin L2 from Stachybotrys chartarum.},
  author={Zahidul Md. Islam and Junko Shinozuka and Jack R. Harkema and James J. Pestka},
  journal={Journal of toxicology and environmental health. Part A},
  year={2009},
  volume={72 20},
  pages={
          1242-51
        }
}
Satratoxin G (SG), a macrocyclic trichothecene produced by Stachybotrys chartarum, induces apoptosis in cultured neuronal cells as well as nasal olfactory sensory neurons (OSN) in the nose and brain of mice exposed intranasally to this toxin. The purposes of this study were to (1) develop a facile method for production and purification of both SG and its putative biosynthetic precursor, roridin L2 (RL2), from S. chartarum cultures and (2) compare their relative neurotoxicity in vitro and in… CONTINUE READING

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