Purification and characterization of the cytoplasmic domain of human receptor-like protein tyrosine phosphatase RPTP mu.

@article{Gebbink1993PurificationAC,
  title={Purification and characterization of the cytoplasmic domain of human receptor-like protein tyrosine phosphatase RPTP mu.},
  author={Martijn F. B. G. Gebbink and Mark H G Verheijen and Gerben C. M. Zondag and Ir W Van Etten and Wouter H Moolenaar},
  journal={Biochemistry},
  year={1993},
  volume={32 49},
  pages={13516-22}
}
RPTP mu is a recently described receptor-like protein tyrosine phosphatase (PTP), the ectodomain of which mediates homophilic cell-cell adhesion. The cytoplasmic part contains two homologous PTP-like domains and a juxtamembrane region that is about twice as large as in other receptor-like PTPs. The entire 80-kDa cytoplasmic part of human RPTP mu was expressed in insect Sf9 cells and its enzymatic activity was characterized after purification to electrophoretic homogeneity. In addition, the… CONTINUE READING