Purification and characterization of the T4 bacteriophage uvsX protein.

  title={Purification and characterization of the T4 bacteriophage uvsX protein.},
  author={Timothy Formosa and Bruce M. Alberts},
  journal={The Journal of biological chemistry},
  volume={261 13},
Gene uvsX of bacteriophage T4 encodes a 40,000-dalton protein that plays a key role in the major pathway for genetic recombination in T4-infected cells. Mutations at the uvsX locus lead to increased sensitivity to various DNA-damaging agents, reduced phage bursts, decreased genetic recombination, and early arrest of DNA synthesis. Like the Escherichia coli recA protein, the purified uvsX protein is a DNA-dependent ATPase that catalyzes pairing between homologous single- and double-stranded DNA… CONTINUE READING


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