Purification and characterization of tenecin 4, a new anti-Gram-negative bacterial peptide, from the beetle Tenebrio molitor.

@article{Chae2012PurificationAC,
  title={Purification and characterization of tenecin 4, a new anti-Gram-negative bacterial peptide, from the beetle Tenebrio molitor.},
  author={Jun-Ho Chae and Kenji Kurokawa and Young-In So and Hyun Ok Hwang and Min-su Kim and Ji-won Park and Yong-Hun Jo and Yong Seok Lee and Bok Luel Lee},
  journal={Developmental and comparative immunology},
  year={2012},
  volume={36 3},
  pages={540-6}
}
The biochemical characterization of novel antimicrobial peptides (AMPs) and the determination of ligand molecules that induce AMP production are essential for understanding the host innate immune response in insects. Here, we purified a new 14-kDa AMP, named tenecin 4, from the larval hemolymph of the beetle Tenebrio molitor. Tenecin 4 contains 14% glycine residues and has moderate similarities both to the C-terminal region of Drosophila attacin and to silk-moth gloverin proteins. Purified… CONTINUE READING