Purification and characterization of recombinant CH3 domain fragment of the CREB-binding protein.

Abstract

CREB-binding protein (CBP) is an important coactivator of basal transcription machinery and a critical regulator of cellular proliferation, differentiation, and apoptosis. It is hypothesized that CBP function is regulated by post-translational modifications, such as phosphorylation and methylation. Specific kinase-mediated phosphorylation of CBP has been… (More)
DOI: 10.1016/j.pep.2009.12.003

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