Purification and characterization of nuclear factors binding to the negative regulatory element D of human apolipoprotein A-II promoter: a negative regulatory effect is reversed by GABP, an Ets-related protein.

@article{Cardot1994PurificationAC,
  title={Purification and characterization of nuclear factors binding to the negative regulatory element D of human apolipoprotein A-II promoter: a negative regulatory effect is reversed by GABP, an Ets-related protein.},
  author={Philippe Jean-Paul Cardot and Dani{\`e}le Pastier and Jean Marc Lacorte and Marise Mangeney and Vassilis I. Zannis and Jean Chambaz},
  journal={Biochemistry},
  year={1994},
  volume={33 40},
  pages={12139-48}
}
We have previously shown that transcription of the human apolipoprotein A-II (apoA-II) gene is controlled by a complex set of regulatory elements [Cardot et al. (1993) Biochemistry 32, 9080-9093]. We have also identified previously described, as well as new activities which bind to these elements and influence to varying degrees the transcription of the apoA-II gene. DNA binding and competition assays indicated that element D binds three new activities, designated AIID1, AIID2, and AIID4, as… CONTINUE READING

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