Purification and characterization of leukotriene A4 hydrolase from Xenopus laevis oocytes.

Abstract

In mammals, leukotriene A4 hydrolase converts leukotriene A4 into the proinflammatory mediator leukotriene B4. We have purified and characterized a non-mammalian leukotriene A4 hydrolase from Xenopus laevis oocytes. This enzyme contains one zinc atom and catalyzes an anion-dependent peptidase activity, two key features of the mammalian enzymes. The amino… (More)

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