Purification and characterization of human laminin-8. Laminin-8 stimulates cell adhesion and migration through alpha3beta1 and alpha6beta1 integrins.

@article{Fujiwara2001PurificationAC,
  title={Purification and characterization of human laminin-8. Laminin-8 stimulates cell adhesion and migration through alpha3beta1 and alpha6beta1 integrins.},
  author={Hironobu Fujiwara and Yamato Kikkawa and Noriko Sanzen and Kiyotoshi Sekiguchi},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 20},
  pages={17550-8}
}
Recently identified laminin isoforms containing the alpha4 chain have been shown to be expressed in the basement membrane of restricted organs such as heart, skeletal muscle, and blood vessels, especially those in embryos. We screened 38 human cell lines for the expression of the laminin alpha4 chain by reverse transcriptase-polymerase chain reaction and found that T98G glioblastoma cells express only alpha4, but not other alpha chains. Laminin-8, an isoform containing the alpha4 and beta1… CONTINUE READING