Purification and characterization of human uroporphyrinogen III synthase expressed in Escherichia coli.

@article{Omata2004PurificationAC,
  title={Purification and characterization of human uroporphyrinogen III synthase expressed in Escherichia coli.},
  author={Yoshiaki Omata and Hiroshi Sakamoto and Yuichiro Higashimoto and Shunsuke Hayashi and Masato Noguchi},
  journal={Journal of biochemistry},
  year={2004},
  volume={136 2},
  pages={211-20}
}
The side-chain asymmetry of physiological porphyrins is produced by the cooperative action of hydroxymethylbilane synthase and uroporphyrinogen (uro'gen) III synthase. Although the role of uro'gen III synthase is essential for the chemistry of porphyrin biosynthesis, many aspects, structural as well as mechanical, of uro'gen III synthase have yet to be… CONTINUE READING