Purification and characterization of N-hydroxy-2-acetylaminofluorene sulfotransferase from rat liver.

  title={Purification and characterization of N-hydroxy-2-acetylaminofluorene sulfotransferase from rat liver.},
  author={S G Wu and Karl David Straub},
  journal={The Journal of biological chemistry},
  volume={251 21},

Figures and Tables from this paper

The identity of alcohol sulfotransferases with hydroxysteroid sulfotransferases.

A hydroxysteroid sulfotransferase from rat liver.

The S-sulfate formation from 4-nitrobenzyl mercaptan in rat liver cytosol.

Arylsulfotransferase IV catalyzed sulfation of 1-naphthalenemethanol.

  • M. DuffelM. Janss
  • Chemistry, Biology
    Advances in experimental medicine and biology
  • 1986
6’7 Benzylic sulfates are electrophilic metabolites and can react with cellular nucleophiles due to the ease with which the sulfate acts as a leaving group, and the ability of the aromatic ring to stabilize a positive charge at the benzylic carbon.

Characterization and expression of hepatic sulfotransferase involved in the metabolism of N-substituted aryl compounds.

An aryl sulfotransferase, whose cDNA was isolated from the rat liver library, was found to catalyze bioactivation of minoxidil through N-O-sulfation and N-sulfation of a carcinogenic heterocyclic

Partial Purification and Characterization of a 3'- Phosphoadenosine 5' -Phosphosulfate: Desulfoglucosinolate Sulfotransferase from Cress (Lepidium sativum).

The kinetics of desulfobenzylglucosinolate sulfation were consistent with a rapid equilibrium ordered mechanism with desulfolysis first and PAPS second, and all other potential substrates tested, including flavonoids, flavonoid glycosides, cinnamic acids, and phenylacetaldoxime, were not sulfated.

Metabolism of benzidine to N-hydroxy-N,N'-diacetylbenzidine and subsequent nucleic acid binding and mutagenicity.

Evidence has been obtained that benzidine metabolism can include the following sequence: benzidine → N-acetylbenzidine→ N,N′-diacetylbenZidine • N-hydroxy-N,N −diacetic acid binding → nucleic acid binding which suggests that BZ can be metabolized to reactive derivatives which may contribute to the induction of tumors.


The Molecular Biology of Cancer, pp. 385-387

  • 1974