Purification and characterization of ascamycin-hydrolysing aminopeptidase from Xanthomonas citri.

@article{Osada1986PurificationAC,
  title={Purification and characterization of ascamycin-hydrolysing aminopeptidase from Xanthomonas citri.},
  author={Hiroyuki Osada and K. Isono},
  journal={The Biochemical journal},
  year={1986},
  volume={233 2},
  pages={459-63}
}
A nucleoside antibiotic, ascamycin (9-beta-[5'-0-(N-L-alanyl) sulphamoyl-D-ribofuranosyl]-2-chloroadenine), has a selective antibacterial activity against Xanthomonas species. When ascamycin was dealanylated, dealanylascamycin showed a broad antibacterial activity against various Gram-negative and Gram-positive bacteria. Xanthomonas citri is susceptible to ascamycin by virtue of the ascamycin-dealanylating enzyme on the cell surface [Osada & Isono (1985) Antimicrob. Agents Chemother. 27, 230… CONTINUE READING