Purification and characterization of aldehyde dehydrogenase from human brain.

@article{Ryzlak1987PurificationAC,
  title={Purification and characterization of aldehyde dehydrogenase from human brain.},
  author={M T Ryzlak and Regina Pietruszko},
  journal={Archives of biochemistry and biophysics},
  year={1987},
  volume={255 2},
  pages={409-18}
}
Aldehyde dehydrogenase (EC 1.2.1.3) has been purified from human brain; this constitutes the first purification to homogeneity from the brain of any mammalian species. Of the three isozymes purified two are mitochondrial in origin (Peak I and Peak II) and one is cytoplasmic (Peak III). By comparison of properties, the cytoplasmic Peak III enzyme could be identified as the same as the liver cytoplasmic E1 isozyme (N.J. Greenfield and R. Pietruszko (1977) Biochim. Biophys. Acta 483, 35-45). The… CONTINUE READING