Purification and characterization of a new cystatin inhibitor from Taiwan cobra (Naja naja atra) venom.

@article{BrillardBourdet1998PurificationAC,
  title={Purification and characterization of a new cystatin inhibitor from Taiwan cobra (Naja naja atra) venom.},
  author={Mich{\`e}le Brillard-Bourdet and V Nguy{\^e}n and M Ferrer-di Martino and Francis L Gauthier and Thierry Moreau},
  journal={The Biochemical journal},
  year={1998},
  volume={331 ( Pt 1)},
  pages={239-44}
}
Cobra cystatin, a new cysteine-proteinase inhibitor of the cystatin superfamily, was isolated from the venom of the Taiwan cobra (Naja naja atra) by affinity chromatography on S-carboxymethylpapain-Sepharose and reverse-phase chromatography. The venom contained two forms of the inhibitor, one of 11870 Da and the other of 12095 Da, as determined by MS, and pI values of 6.2 and 6.1. Cobra cystatin strongly inhibits cysteine proteinases of the papain family, but not calpain. Papain, cathepsin L… CONTINUE READING

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