Purification and characterization of a cardioexcitatory neuropeptide from the central ganglia of a bivalve mollusc.

@article{Price1977PurificationAC,
  title={Purification and characterization of a cardioexcitatory neuropeptide from the central ganglia of a bivalve mollusc.},
  author={David A. Price and Michael J. Greenberg},
  journal={Preparative biochemistry},
  year={1977},
  volume={7 3-4},
  pages={
          261-81
        }
}
We have purified a cardioexcitatory substance, previously designated peak C, from ganglia of the Sunray Venus clam, Macrocallista nimbosa. Low concentrations (10(-9)-10(-8) M) of this substance not only excite the isolated clam heart, but also produce tonic contractions of the isolated radula protractor muscle of the whelk, Busycon contrarium. These two muscle preparations have therefore been used as a parallel bioassay for peak C. Peak C is inactivated by proteolytic enzymes, has an… CONTINUE READING
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