Purification and characterization of a myotoxic phospholipase A2 from Indian cobra (Naja naja naja) venom.

@article{Bhat1989PurificationAC,
  title={Purification and characterization of a myotoxic phospholipase A2 from Indian cobra (Naja naja naja) venom.},
  author={Mahalingeshwara K. Bhat and T. Veerabasappa Gowda},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={1989},
  volume={27 8},
  pages={
          861-73
        }
}
A major phospholipase A2 (NN-XIII-PLA2) which constitutes 20% of the whole Naja naja naja venom was purified to homogeneity on CM-Sephadex C-25 column chromatography. NN-XIII-PLA2 is a basic protein with a mol. wt of 11,200 by SDS-PAGE. This enzyme has low enzymatic activity but is more toxic to mice than the whole venom. The LD50 value (i.p.) of NN-XIII-PLA2 is 2.4 mg/kg body weight (whole venoms LD50 is 2.8 mg/kg body weight). It induces neurotoxic-like signs in experimental animals. It… CONTINUE READING
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