Purification and characterization of a molluscan egg-specific NADase, a second-messenger enzyme.

@article{Hellmich1991PurificationAC,
  title={Purification and characterization of a molluscan egg-specific NADase, a second-messenger enzyme.},
  author={Mark R. Hellmich and Felix Strumwasser},
  journal={Cell regulation},
  year={1991},
  volume={2 3},
  pages={
          193-202
        }
}
An egg-specific NADase has been purified to homogeneity from the ovotestis of the opisthobranch mollusk Aplysia californica. Unlike other NADases, the Aplysia enzyme generates primarily cyclic-ADP-ribose (cADPR) rather than ADP-ribose from NAD. cADPR has been shown to stimulate the release of Ca2+ from microsomes prepared from sea urchin egg and, when injected into intact eggs, to activate the cortical reaction, multiple nuclear cycles, and DNA synthesis. The Aplysia enzyme was initially… CONTINUE READING
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