Purification and characterization of TTFI, a factor that mediates termination of mouse ribosomal DNA transcription.

@article{Bartsch1988PurificationAC,
  title={Purification and characterization of TTFI, a factor that mediates termination of mouse ribosomal DNA transcription.},
  author={Ingrid Bartsch and C Schoneberg and Ingrid Grummt},
  journal={Molecular and cellular biology},
  year={1988},
  volume={8 9},
  pages={3891-7}
}
Termination of rRNA gene transcription is dependent on an 18-base-pair sequence motif, AGGTCGAC CAG AT TA NTCCG (the Sal box), which is present several times in the spacer region downstream of the 3' end of the pre-rRNA coding region. We report here the purification to molecular homogeneity of a nuclear factor which specifically interacts with the Sal box element. Addition of the isolated protein to S-100 extracts which contain low levels of the Sal box-binding protein and are therefore… CONTINUE READING
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