Purification and characterization of 9-O-acetylated sialoglycoproteins from leukemic cells and their potential as immunological tool for monitoring childhood acute lymphoblastic leukemia.

@article{Pal2004PurificationAC,
  title={Purification and characterization of 9-O-acetylated sialoglycoproteins from leukemic cells and their potential as immunological tool for monitoring childhood acute lymphoblastic leukemia.},
  author={S. Pal and S. Ghosh and C. Mandal and G. Kohla and R. Brossmer and R. Isecke and A. Merling and R. Schauer and R. Schwartz-Albiez and D. K. Bhattacharya},
  journal={Glycobiology},
  year={2004},
  volume={14 10},
  pages={
          859-70
        }
}
Sialic acids as terminal residues of oligosaccharide chains play crucial roles in several cellular recognition events. Exploiting the selective affinity of Achatinin-H toward N-acetyl-9-O-acetylneuraminic acid-alpha2-6-GalNAc, we have demonstrated the presence of 9-O-acetylated sialoglycoproteins (Neu5,9Ac(2)-GPs) on lymphoblasts of 70 children with acute lymphoblastic leukemia (ALL) and on leukemic cell lines by fluorimetric HPLC and flow cytometric analysis. This study aims to assess the… Expand
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References

SHOWING 1-10 OF 66 REFERENCES
Identification of 9-O acetyl sialoglycoconjugates (9-OAcSGs) as biomarkers in childhood acute lymphoblastic leukemia using a lectin, AchatininH, as a probe
  • 63
  • Highly Influential
  • PDF
Identification of 9-O-acetylated sialoglycans on peripheral blood mononuclear cells in Indian Visceral Leishmaniasis
  • 15
Identification and characterization of adsorbed serum sialoglycans on Leishmania donovani promastigotes.
  • 57
  • PDF
Antibodies against 9-O-acetylated sialoglycans: a potent marker to monitor clinical status in childhood acute lymphoblastic leukemia.
  • 24
  • PDF
O-acetylation of sialic acids.
  • 88
Detection of sialic acids and gangliosides with special reference to 9-O-acetylated species in basaliomas and normal human skin.
  • 43
O-acetyl sialic acid specific IgM in childhood acute lymphoblastic leukaemia
  • 25
...
1
2
3
4
5
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