Purification and assay of the human INO80 and SRCAP chromatin remodeling complexes.

@article{Cai2006PurificationAA,
  title={Purification and assay of the human INO80 and SRCAP chromatin remodeling complexes.},
  author={Yong Cai and Jingji Jin and Aaron J Gottschalk and Tingting Yao and Joan W Conaway and Ronald C. Conaway},
  journal={Methods},
  year={2006},
  volume={40 4},
  pages={312-7}
}
Chromatin modifying and remodeling enzymes play critical roles in many aspects of chromosome biology including transcription, replication, recombination, and repair. Our laboratory recently identified and characterized two multisubunit human chromatin remodeling enzymes designated the INO80 and SRCAP complexes. Mechanistic studies revealed that the human INO80 complex catalyzes nucleosome sliding and the SRCAP complex catalyzes ATP-dependent exchange of histone H2A/H2B dimers containing the… CONTINUE READING

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