Purification and assay methods for angiotensin-converting enzyme.

  title={Purification and assay methods for angiotensin-converting enzyme.},
  author={Qing Cheng Meng and Suzanne Oparil},
  journal={Journal of chromatography. A},
  volume={743 1},
Angiotensin-converting enzyme (ACE; EN is a peptidyl dipeptide hydrolase that removes the carboxyl terminal His-Leu from angiotensin I to produce the octapeptide angiotensin II. In addition, ACE inactivates bradykinin, a vasodilator peptide/mediator of inflammation, as well as substance P, enkephalins and endorphins. Because of the importance of ACE and its active site-directed inhibitors in the pathogenesis and treatment of cardiovascular disorders such as hypertension and heart… CONTINUE READING