Purification and Characterization of a Novel Metalloprotease from Human Brain with the Ability to Cleave Substrates Derived from the N-Terminus of β-Amyloid Protein

@inproceedings{Schonlein1994PurificationAC,
  title={Purification and Characterization of a Novel Metalloprotease from Human Brain with the Ability to Cleave Substrates Derived from the N-Terminus of β-Amyloid Protein},
  author={C. Schonlein and Jochen Loffler and Gerda Huber},
  year={1994}
}
Abstract The main component of amyloid plaques in Alzheimer′s disease (AD) is the β-amyloid peptide (β/A4), derived from β-amyloid precursor proteins (β-APPs). In order to identify proteases possibly involved in the cleavage at the N-terminal site of β/A4 a chromogenic peptide corresponding to this region of β-APP was used. Here the purification and characterization of a new human brain protease with the ability to cleave the β-APP peptide as well as β-APP in vitro are described. The enzyme has… CONTINUE READING