Purification and Analysis of Recombinant 11 S Activators of the 20 S Proteasome : Trypanosoma brucei PA 26 and Human PA


Proteasomes perform the bulk of nonlysosomal degradation of aberrant, damaged, misfolded, and naturally short‐lived regulatory proteins in eukaryotic cells. They are 700‐kDa assemblies whose hollow architecture sequesters the proteolytic sites inside a central chamber, thereby ensuring that the activity of isolated proteasomes is repressed. In vivo… (More)


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