Purification, primary structures and evolution of coagulant proteases from Deinagkistrodon actus venom.

@article{Nikandrov2005PurificationPS,
  title={Purification, primary structures and evolution of coagulant proteases from Deinagkistrodon actus venom.},
  author={Nikolai N Nikandrov and Masanobu Deshimaru and Ayako Tani and Takahito Chijiwa and Hiroki Shibata and Chang-Chun Chang and Yasuyuki Fukumaki and Tatsumi Ito and Motonori Ohno},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={2005},
  volume={46 8},
  pages={907-17}
}
Deinagkistrodon (formerly Agkistrodon) actus (Taiwan) snake venom was found to contain at least seven closely related coagulant proteases. One of them, named actibin, was purified to homogeneity by means of four chromatographic steps. Actibin acted on fibrinogen to form fibrin clots with extremely high specific activity of 1,630 NIH units/mg and… CONTINUE READING