Purification, crystallization and preliminary crystallographic studies of Lys48-linked polyubiquitin chains.

Abstract

Post-translational modification of proteins by covalent attachment of ubiquitin regulates diverse cellular events. A Lys48-linked polyubiquitin chain is formed via an isopeptide bond between Lys48 and the C-terminal Gly76 of different ubiquitin molecules. The chain is attached to a lysine residue of a substrate protein, which leads to proteolytic… (More)
DOI: 10.1107/S1744309110018804

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