Purification, crystallization and preliminary X-ray analysis of an unusual thioredoxin from the gastric pathogen Helicobacter pylori.

Abstract

Thioredoxin-2 (HP1458) from Helicobacter pylori is a member of the thioredoxin family, but possesses the unusual active-site motif CPDC (compared with CGPC in other thioredoxins). H. pylori is deficient in the glutaredoxin system, making the thioredoxin system the sole reduction system in the bacterium and critical for its ability to survive oxidative… (More)

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