Purification, characterization, molecular cloning, and subcellular distribution of neutral ceramidase of rat kidney.

@article{Mitsutake2001PurificationCM,
  title={Purification, characterization, molecular cloning, and subcellular distribution of neutral ceramidase of rat kidney.},
  author={Susumu Mitsutake and Minobu Tani and Nozomu Okino and Koshi Mori and Sachiyo Ichinose and Akira Omori and Hiroshi Iida and Takashi Nakamura and Masaki Ito},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 28},
  pages={
          26249-59
        }
}
Previously, we reported two types of neutral ceramidase in mice, one solubilized by freeze-thawing and one not. The former was purified as a 94-kDa protein from mouse liver, and cloned (Tani, M., Okino, N., Mori, K., Tanigawa, T., Izu, H., and Ito, M. (2000) J. Biol. Chem. 275, 11229--11234). In this paper, we describe the purification, molecular cloning, and subcellular distribution of a 112-kDa membrane-bound neutral ceramidase of rat kidney, which was completely insoluble by freeze-thawing… CONTINUE READING
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