Purification, bioactivity, and secondary structure analysis of mouse and human macrophage migration inhibitory factor (MIF).

@article{Bernhagen1994PurificationBA,
  title={Purification, bioactivity, and secondary structure analysis of mouse and human macrophage migration inhibitory factor (MIF).},
  author={J{\"u}rgen Bernhagen and Robert Mitchell and Thierry Calandra and Wolfgang Voelter and Anthony Cerami and Richard Bucala},
  journal={Biochemistry},
  year={1994},
  volume={33 47},
  pages={14144-55}
}
The cytokine macrophage migration inhibitory factor (MIF) has been identified to be secreted by the pituitary gland and the monocyte/macrophage and to play an important role in endotoxic shock. Despite the recent molecular cloning of a human T-cell MIF, characterization of the biochemical and biological properties of this protein has remained incomplete because substantial quantities of purified, recombinant, or native MIF have not been available. We describe the cloning of mouse MIF from… CONTINUE READING
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