Purging of peripheral blood stem cell transplants in AML: a predictive model based on minimal residual disease burden.

@article{Feller2005PurgingOP,
  title={Purging of peripheral blood stem cell transplants in AML: a predictive model based on minimal residual disease burden.},
  author={Nicole Feller and Martine C Jansen-van der Weide and Marjolein A van der Pol and Guus A H Westra and Gert Jan Ossenkoppele and Gerrit J Schuurhuis},
  journal={Experimental hematology},
  year={2005},
  volume={33 1},
  pages={120-30}
}
OBJECTIVE Minimal residual disease (MRD) present in peripheral blood stem cell (PBSC) products of AML patients may contribute to relapse. Our goal was to 1) predict leukemia recurrence based on the frequency of MRD present in PBSC products, 2) establish the efficacy of different purging procedures, and 3) integrate this into a model that enables to predict whether or not to purge. METHODS Minimal residual disease was measured with flow cytometry using leukemia-associated phenotypes as… CONTINUE READING