Puralpha, a single-stranded DNA binding protein, suppresses the enhancer activity of cAMP response element (CRE).

@article{Sadakata2000PuralphaAS,
  title={Puralpha, a single-stranded DNA binding protein, suppresses the enhancer activity of cAMP response element (CRE).},
  author={Tetsushi Sadakata and Chuan Hui Kuo and Hitoshi Ichikawa and Eiichi Nishikawa and Shengpan Niu and Emi Kumamaru and Naomasa Miki},
  journal={Brain research. Molecular brain research},
  year={2000},
  volume={77 1},
  pages={47-54}
}
Puralpha, a single-stranded DNA binding protein, recognizes a PUR element (GGN repeat). We have reported that Puralpha binds to a single-stranded oligonucleotide probe containing the cAMP response element (CRE) of rat somatostatin gene using a gel mobility shift assay. Here, we showed that Puralpha binds to the probe only in the presence of a PUR element by a more detailed characterization. We also examined the effects of Puralpha on the enhancer activity of the somatostatin CRE in PC12 cells… CONTINUE READING
3 Citations
0 References
Similar Papers