Pupil diameter covaries with BOLD activity in human locus coeruleus.

@article{Murphy2014PupilDC,
  title={Pupil diameter covaries with BOLD activity in human locus coeruleus.},
  author={Peter R. Murphy and Redmond G. O'Connell and Michael O'Sullivan and I. H. Robertson and Joshua H. Balsters},
  journal={Human brain mapping},
  year={2014},
  volume={35 8},
  pages={4140-54}
}
The locus coeruleus-noradrenergic (LC-NA) neuromodulatory system has been implicated in a broad array of cognitive processes, yet scope for investigating this system's function in humans is currently limited by an absence of reliable non-invasive measures of LC activity. Although pupil diameter has been employed as a proxy measure of LC activity in numerous studies, empirical evidence for a relationship between the two is lacking. In the present study, we sought to rigorously probe the… CONTINUE READING
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