Punicic Acid a Conjugated Linolenic Acid Inhibits TNFα-Induced Neutrophil Hyperactivation and Protects from Experimental Colon Inflammation in Rats

@inproceedings{Boussetta2009PunicicAA,
  title={Punicic Acid a Conjugated Linolenic Acid Inhibits TNFα-Induced Neutrophil Hyperactivation and Protects from Experimental Colon Inflammation in Rats},
  author={Tarek Boussetta and Houssam Raad and Philippe Lett{\'e}ron and Marie-Anne Gougerot-Pocidalo and Jean-Claude Marie and Fathi Driss and Jamel El-Benna},
  booktitle={PloS one},
  year={2009}
}
BACKGROUND Neutrophils play a major role in inflammation by releasing large amounts of ROS produced by NADPH-oxidase and myeloperoxidase (MPO). The proinflammatory cytokine TNFalpha primes ROS production through phosphorylation of the NADPH-oxidase subunit p47phox on Ser345. Conventional anti-inflammatory therapies remain partially successful and may have side effects. Therefore, regulation of neutrophil activation by natural dietary components represents an alternative therapeutic strategy in… CONTINUE READING

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Pomegranate Seed Oil ( Punica Granatum L . ) : A Source of Punicic Acid ( Conjugated α-Linolenic Acid )

Illana Louise Pereira Melo, Eliane Bonifácio Teixeira de, Carvalho, N. S. Marin-Huachaca
  • 2014
VIEW 3 EXCERPTS
CITES BACKGROUND & RESULTS
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